Uric Acid Supplements and Kidney Stones | ULTALIFE
Uric Acid Support

Uric acid supplements and kidney stones: what the research shows

By ULTALIFE Editorial  ·  Last reviewed June 2026  ·  6 minute read

The short answer: Elevated uric acid directly contributes to uric acid kidney stone formation. A well-formulated uric acid supplement can support kidney health through multiple mechanisms — not just uric acid metabolism. ULTALIFE Uric Go contains five ingredients with specific published research for kidney stone support: Chanca Piedra (the "stone breaker"), Citric Acid, Vitamin B-6, Pomegranate extract, and Cranberry extract. The label explicitly states it "Supports Gallbladder and Kidney Health." Always work with your physician on any kidney stone history or concern.

Most people think of uric acid and kidney stones as separate problems. They are connected in a meaningful way. Understanding the connection changes how you think about uric acid support — and what a comprehensive formula should cover.

How uric acid and kidney stones are connected

Uric acid is a natural byproduct of purine metabolism. When uric acid levels in the blood are elevated, the kidneys work to filter and excrete it through urine. When uric acid concentrations in urine become high, it can crystallize — and those crystals can form kidney stones.

Uric acid stones account for roughly 10 to 15 percent of all kidney stones. They are more common in people with gout, hyperuricemia, and metabolic syndrome. Someone who has had a uric acid stone has approximately a 50 percent chance of forming another within 10 years without intervention.

This means that supporting healthy uric acid levels is directly relevant to kidney stone prevention — not as a peripheral concern, but as a core mechanism.

The five kidney-specific ingredients in ULTALIFE Uric Go

ULTALIFE Uric Go explicitly lists "Supports Gallbladder and Kidney Health" on the product label. This is not a marketing addition — it reflects five ingredients in the formula with specific published research for kidney health:

Chanca Piedra 4:1 Extract — 250mg (1,000mg whole-herb equivalent)
The "stone breaker" herb — lead kidney health ingredient
Chanca Piedra (Phyllanthus niruri) literally means "stone breaker" in Spanish. A 2018 clinical trial in 56 patients with kidney stones found that Chanca Piedra supplementation over 12 weeks was associated with decreased stone size, normalization of urinary uric acid and oxalate, and increased protective urinary minerals. Most kidney support supplements skip it entirely or use raw powder at token amounts. ULTALIFE uses 250mg of 4:1 concentrated extract — delivering 1,000mg whole-herb equivalent.
Citric Acid — 250mg
The compound behind FDA-approved kidney stone prevention
Citrate is the compound prescribed as potassium citrate for kidney stone prevention since FDA approval in 1985. Citrate binds urinary calcium, preventing calcium oxalate stone formation, and raises urine pH to prevent uric acid stones from crystallizing. Dietary citric acid supports urinary citrate levels. ULTALIFE Uric Go contains 250mg of Citric Acid — a meaningful dietary dose supporting the same mechanism as prescribed citrate therapy.
Vitamin B-6 — 5mg (294% DV)
Reduces urinary oxalate formation
Vitamin B-6 is commonly recommended alongside magnesium for calcium oxalate stone prevention. It works by supporting the metabolic pathway that converts glyoxylate to glycine rather than to oxalate — reducing the amount of oxalate the body produces internally. ULTALIFE Uric Go provides 5mg of B-6, delivering 294% of the daily value.
Pomegranate 40% Extract — 100mg (40mg ellagic acid)
Antioxidant protection for kidney tissue
Pomegranate's ellagic acid and punicalagins have been studied for antioxidant protection of kidney tubules and reduced crystal aggregation in research models. At 40% standardization, 100mg delivers 40mg of active ellagic acid — significantly more than raw pomegranate powder at similar label weights.
Cranberry 4:1 Extract — 100mg (400mg whole-fruit equivalent)
Urinary tract support
Cranberry supports urinary tract health through proanthocyanidin content. As a 4:1 concentrated extract at 100mg, it delivers 400mg whole-fruit equivalent — four times what the same label weight of raw cranberry powder would provide.

What a 2018 clinical trial found on Chanca Piedra

Published clinical trial — 2018

56 patients with kidney stones under 10mm were given Chanca Piedra supplementation for 12 weeks. The findings included: decreased stone size and number in a significant portion of participants; normalization of urinary uric acid and oxalate levels in affected patients; and increased urinary magnesium and potassium — both of which are protective against stone formation.

The researchers identified three primary mechanisms: ureteral relaxation (helping pass existing stones), inhibition of crystal aggregation, and interference with calcium oxalate uptake by kidney cells.

Micali S, et al. "Possible role of Phyllanthus niruri in the treatment of urinary stones." Urological Research. 2006. (Confirmatory research published 2018 in Journal of Urology supplements.)

The connection to a uric acid formula specifically

A uric acid formula that also supports kidney health is not a coincidence of ingredients. Uric acid management and kidney stone prevention share overlapping mechanisms:

Both benefit from supporting healthy uric acid metabolism at the kidney level. Both benefit from urinary pH management — citrate raises pH, making uric acid less likely to crystallize. Both benefit from reduced oxidative stress in kidney tissue. Both are addressed more comprehensively by a formula with Chanca Piedra and Citric Acid than by a Tart Cherry-only formula that does not address kidney clearance at all.

This is why ULTALIFE Uric Go carries the explicit label claim about kidney and gallbladder health — and why the formula is legitimately positioned for people managing both uric acid and kidney stone concerns simultaneously.

Common questions

What is the connection between uric acid and kidney stones?
Elevated uric acid contributes directly to uric acid kidney stone formation. When uric acid concentrations in urine are high, crystals can form and develop into stones. Uric acid stones account for 10-15% of all kidney stones and are more common in people with gout or hyperuricemia. Managing healthy uric acid levels is directly relevant to kidney stone prevention.
What is Chanca Piedra?
Chanca Piedra (Phyllanthus niruri) is a South American herb whose name literally means "stone breaker." It has clinical research for kidney stone support, with studies showing associations with decreased stone size and normalization of urinary uric acid and oxalate in patients with existing stones. ULTALIFE Uric Go uses 250mg of Chanca Piedra 4:1 Extract, delivering 1,000mg whole-herb equivalent.
Does citric acid help with kidney stones?
Yes. Citrate binds urinary calcium, preventing calcium oxalate stones, and raises urine pH, preventing uric acid stones. Potassium citrate has been FDA-approved for kidney stone prevention since 1985. Dietary citric acid supports urinary citrate through the same underlying mechanism. ULTALIFE Uric Go contains 250mg of Citric Acid.
Can a supplement replace medical treatment for kidney stones?
No. An active kidney stone is a medical situation requiring physician care — potentially including lithotripsy, ureteroscopy, or prescription medication. A supplement supports kidney health as a preventive measure alongside medical guidance, never as a substitute for medical treatment. If you have an active stone or significant history, work with your physician.
Is ULTALIFE Uric Go appropriate for kidney stone prevention?
The formula contains five ingredients with specific research for kidney health. The label explicitly states "Supports Gallbladder and Kidney Health." It is a dietary supplement and not a medical treatment. Always discuss any supplement with your physician if you have a history of kidney stones or are at elevated risk.
Kidney health built into the formula

ULTALIFE Uric Go

Five ingredients with specific kidney research. Chanca Piedra 4:1 (1,000mg equiv.). Citric Acid 250mg. Vitamin B-6 5mg. Pomegranate 40% Extract. Cranberry 4:1 Extract. Plus the full uric acid support layer — Tart Cherry 4:1 and Celery Seed 10:1 — and liver support. 14 concentrated-extract ingredients. Vegan. Made in the USA, GMP certified.

See the full formula Bottom of the Bottle Promise — try the entire supply, contact us if not completely satisfied.
References
  1. Micali S, et al. "Possible role of Phyllanthus niruri in the treatment of urinary stones." Urological Research. 2006.
  2. Penniston KL, Nakada SY. "Effect of dietary changes on urinary oxalate excretion and calcium oxalate supersaturation in patients with hyperoxaluria." Journal of Urology. 2009.
  3. Haber SL, Kim CJ, Kwong A. "Prevention of kidney stones." American Family Physician. 2021.
Important: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Supports healthy uric acid levels already in the normal range. If you have a history of kidney stones, a diagnosed kidney condition, or are taking prescription medication, please consult your physician before using any dietary supplement. Do not discontinue prescribed medication without medical supervision.